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  • NYU Dataset

    Synaptic Vesicle Traffic is Supported by Transient Actin Filaments

    Authors
    Nicolas Chenouard
    Feng Xuan
    Richard W. Tsien
    Description

    Synaptic vesicles (SVs) play a key role in synaptic transmission. This study used time-lapse microscopy to demonstrate two distinct mechanisms of vesicle traffic along axons. They utilized specific pharmacological interventions along with imaging of transient actin polymerization, and traffic of recycling SVs loaded with single quantum dots to characterize the underlying axonal actin structures. For...

    Subject
    Neuroscience
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    Author Approval Required
  • NYU Dataset

    GADD34 Promotes Fast Dephosphorylation of eIF2α and Elevation of Neuronal Protein Synthesis

    Authors
    Mauricio M. Oliveira
    Muhaned Mohamed
    Megan K. Elder
    Keylin Banegas-Morales
    7 more author(s)...
    Description

    This study examined the molecular pathways of translational control that are triggered by neuronal stimulation with brain-derived neurotrophic factor (BDNF). For the study, primary rodent neurons were exposed to BDNF and then examined for GADD34 protein levels. GADD34 is a protein phosphatase 1-targeting protein that directly binds to eukaryotic initiation factor 2α (eIF2α). This promotes eIF2α dephosphorylation...

    Subject
    Genomics
    Neuroscience
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    Free to All