-
Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Datasets
- Alternate Title(s)
- PLCO
- Description
The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was a large randomized controlled trial that assessed whether certain screening practices decreased deaths from prostate, lung, colorectal and ovarian cancer. Approximately 155,000 men and women aged 55 to 74 years old were enrolled from 10 screening centers across the United States between November 1993 and July 2001. Participants...
- Subject
-
CancerChronic DiseaseHealth Care System
- Access Rights
- Application Required
- Local Expert
- Richard B. Hayes
-
NYU Dataset
Condensation of ORF1p is Critical for LINE-1 Retrotransposition
- Authors
- Srinjoy SilSarah KeeganFarida EttefaLance T. Denes2 more author(s)...
- Description
Long interspersed element-1 (LINE-1) is an autonomously active retrotransposon in the human genome. The LINE-1 mRNA encodes two proteins, ORF1p and ORF2p, which are essential for retrotransposition. This study showed that electrostatic interactions and trimer conformational dynamics together tune the properties of ORF1p assemblies to allow for efficient LINE-1 ribonucleoprotein complex formation in...
- Subject
-
Genomics
- Access Rights
- Free to All
