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  • NYU Dataset

    Direct RNA Sequencing Characterized Complex Viral Transcriptomes

    Authors
    Daniel P. Depledge
    Kalanghad Puthankalam Srinivas
    Tomohiko Sadaoka
    Devin Bready
    4 more author(s)...
    Description

    This dataset was collected to show that direct RNA sequencing using nanopore arrays is an alternative to conventional RNA sequencing approaches, which are complicated by high gene density, overlapping reading frames, and complex splicing patterns. In direct RNA sequencing, individual polyadenylated RNAs are sequenced directly. For this study, direct RNA sequencing was used to profile the herpes simplex...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Single-Cell Transcriptomics Identifies Gadd45b as a Regulator of Herpesvirus-Reactivating Neurons

    Authors
    Hui-Lan Hu
    Kalanghad P. Srinivas
    Shuoshuo Wang
    Moses V. Chao
    5 more author(s)...
    Description

    Single‐cell RNA sequencing (scRNA‐seq) has not been effectively used for exploring the interactions between the host cell and viral pathogens in latently infected cells. Therefore, this study used scRNA‐seq and single‐molecule sensitivity fluorescent in situ hybridization technologies to investigate host single‐cell transcriptome changes upon the reactivation of a human neurotropic virus, herpes simplex...

    Subject
    Genomics
    Access Rights
    Free to All