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NYU Dataset
Transposon Insertion Profiling by Sequencing (TIPseq) Utilized for LINE-1 Mapping in Single Cells
- Authors
- Wilson McKerrowZuojian TangJared P. SterankaLindsay M. Payer5 more author(s)...
- Description
This dataset was compiled to determine a genome-wide long interspersed element-1 (LINE-1) insertion site mapping method for bulk DNA. This study has shown that transposon insertion profiling by sequencing (TIPseq) is a method that can be used for LINE-1 mapping in single cells. Live GM12878 lymphoblastoid cells were used for this study. The dataset contains sequencing data as well as supplementary...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Acetyl-L-Carnitine Deficiency in Patients with Major Depressive Disorder
- Authors
- Carla NascaBenedetta BigioFrancis S. LeeSarah P. Young9 more author(s)...
- Description
This study identified biological targets in major depressive disorder (MDD). Acetyl-l-carnitine (LAC), which is critical for hippocampal function and several behavioral domains, has rapid and enduring antidepressant like effects in LAC deficient rodents. As a result, this study examined LAC levels in humans. Following an initial phone screen, potential participants were evaluated in person to determine...
- Subject
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Neuroscience
- Access Rights
- Application RequiredAuthor Approval Required
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NYU Dataset
NOGOB Receptor Deficiency Increases Cerebrovascular Permeability and Hemorrhage
- Authors
- Zhi FangXiaoran SunXiang WangJi Ma6 more author(s)...
- Description
Cerebral cavernous malformation (CCM) lesions are caused by loss of function of CCM genes. Previous study showed that NOGOB receptor (NGBR) knockout in endothelial cells results in cerebrovascular lesions in the mouse embryo. However, the molecular mechanism by which NGBR regulates CCM1/2 expression has not been explained. This study used RNA sequencing analysis to determine the alteration of transcriptomic...
- Subject
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Genomics
- Access Rights
- Free to All
