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NYU Dataset
NOGOB Receptor Deficiency Increases Cerebrovascular Permeability and Hemorrhage
- Authors
- Zhi FangXiaoran SunXiang WangJi Ma6 more author(s)...
- Description
Cerebral cavernous malformation (CCM) lesions are caused by loss of function of CCM genes. Previous study showed that NOGOB receptor (NGBR) knockout in endothelial cells results in cerebrovascular lesions in the mouse embryo. However, the molecular mechanism by which NGBR regulates CCM1/2 expression has not been explained. This study used RNA sequencing analysis to determine the alteration of transcriptomic...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Single Cell RNA Sequencing of Human Cornea Organoids Identifies Cell Fates
- Authors
- George MaitiMaithe Rocha Monteiro de BarrosNan HuIgor Dolgalev5 more author(s)...
- Description
The cornea is the outermost transparent layer of the eye that serves as a protective barrier and studying the cornea can be crucial for understanding human corneal diseases. Although several studies have examined the single-cell transcriptomic composition of the human cornea, its organoids have not been examined similarly. This study explained the transcriptomic cell fate of human cornea organoids...
- Subject
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AnatomyGenomics
- Access Rights
- Free to All
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NYU Dataset
Glucose Transporter 1 is Essential to Maintain Brain Endothelial Cell Homeostasis Under Hyperglycemia Condition
- Authors
- Benjamin MiaoMohammad Sarif MohiuddinRashu BaruaMd Wahiduzzaman6 more author(s)...
- Description
Glucose transporter-1 (GLUT1) is known for regulating glucose uptake in brain endothelial cells. This study demonstrated the importance of GLUT1 in preserving brain endothelial cell homeostasis beyond regulating glucose uptake. Bulk RNA sequencing was used to analyze transcriptomic alterations under hyperglycemia and GLUT1 deficiency conditions to elucidate the GLUT1-mediated protective mechanism....
- Subject
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Genomics
- Access Rights
- Free to All