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  • NYU Dataset

    NOGOB Receptor Deficiency Increases Cerebrovascular Permeability and Hemorrhage

    Authors
    Zhi Fang
    Xiaoran Sun
    Xiang Wang
    Ji Ma
    6 more author(s)...
    Description

    Cerebral cavernous malformation (CCM) lesions are caused by loss of function of CCM genes. Previous study showed that NOGOB receptor (NGBR) knockout in endothelial cells results in cerebrovascular lesions in the mouse embryo. However, the molecular mechanism by which NGBR regulates CCM1/2 expression has not been explained. This study used RNA sequencing analysis to determine the alteration of transcriptomic...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Single Cell RNA Sequencing of Human Cornea Organoids Identifies Cell Fates

    Authors
    George Maiti
    Maithe Rocha Monteiro de Barros
    Nan Hu
    Igor Dolgalev
    5 more author(s)...
    Description

    The cornea is the outermost transparent layer of the eye that serves as a protective barrier and studying the cornea can be crucial for understanding human corneal diseases. Although several studies have examined the single-cell transcriptomic composition of the human cornea, its organoids have not been examined similarly. This study explained the transcriptomic cell fate of human cornea organoids...

    Subject
    Anatomy
    Genomics
    Access Rights
    Free to All