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NYU Dataset
An eIF3d-Dependent Switch Regulates Human Cytomegalovirus Replication
- Authors
- Letitia ThompsonDaniel P. DepledgeHannah M. BurgessIan Mohr
- Description
Gene expression rapidly responds to physiological stress like virus infection in part via the control of mRNA translation. However, how translation of virus and host mRNAs are regulated during infection stress remains unknown. This study showed that protein synthesis in human cytomegalovirus (HCMV)-infected cells unexpectedly becomes progressively reliant upon eIF3d, which is a mRNA cap-binding protein...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Fluoride Exposure Alters Calcium Signaling and Mitochondrial Function in Enamel Cells
- Authors
- Francisco J. AulestiaJohnny GroelingGuilherme H. Souza BomfimVeronica Costiniti8 more author(s)...
- Description
Fluoride is a naturally occurring mineral that helps build strong teeth and prevent cavities. However, excessive fluoride intake causes dental fluorosis, which are enamel defects that can increase the risk of tooth decay. This study examined the effects of fluoride exposure in enamel cells to assess its impact on calcium signaling. For their investigation, they isolated primary EO cells from Sprague...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
FITM2 Deficiency Promotes Hepatic ER Stress in Vitro and in Vivo
- Authors
- Haizhen WangCyrus NikainKonstantinos I. FortounasJaume Amengual14 more author(s)...
- Description
This study examined the role of hepatic FITM2, an endoplasmic reticulum (ER) protein, in the partitioning of newly-synthesized triglyceride between the ER, lipid droplets, and nascent very low density lipoprotein (VLDL) particles in vitro and in vivo. The experiments were conducted using a rat hepatic cell line (McA cells) and mice. Effects of FITM2 deficiency on VLDL assembly and secretion in vitro...
- Subject
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Proteomics
- Access Rights
- Application RequiredAuthor Approval Required
