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  • NYU Dataset

    Novel pH Modulation of Lysosomes Through β2-Adrenergic Regulation of ClC-7 in Alzheimer’s Disease

    Authors
    Ju-Hyun Lee
    Devin M. Wolfe
    Sandipkumar Darji
    Mary Kate McBrayer
    5 more author(s)...
    Description

    Lysosomal dysfunction plays a key role in the pathogenesis of Alzheimer’s disease and Parkinson’s disease. In early onset of Alzheimer’s disease, there is loss of Presenilin-1 (PSEN1) function. The loss of PSEN1 function interferes with ER to lysosome delivery of chloride channel-7. For this study, isoproterenol and related β2-adrenergic agonists was used to reverse lysosomal chloride deficits in murine...

    Subject
    Genomics
    Neuroscience
    Access Rights
    Free to All
  • NYU Dataset

    An eIF3d-Dependent Switch Regulates Human Cytomegalovirus Replication

    Authors
    Letitia Thompson
    Daniel P. Depledge
    Hannah M. Burgess
    Ian Mohr
    Description

    Gene expression rapidly responds to physiological stress like virus infection in part via the control of mRNA translation. However, how translation of virus and host mRNAs are regulated during infection stress remains unknown. This study showed that protein synthesis in human cytomegalovirus (HCMV)-infected cells unexpectedly becomes progressively reliant upon eIF3d, which is a mRNA cap-binding protein...

    Subject
    Genomics
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    Free to All
  • NYU Dataset

    Fluoride Exposure Alters Calcium Signaling and Mitochondrial Function in Enamel Cells

    Authors
    Francisco J. Aulestia
    Johnny Groeling
    Guilherme H. Souza Bomfim
    Veronica Costiniti
    8 more author(s)...
    Description

    Fluoride is a naturally occurring mineral that helps build strong teeth and prevent cavities. However, excessive fluoride intake causes dental fluorosis, which are enamel defects that can increase the risk of tooth decay. This study examined the effects of fluoride exposure in enamel cells to assess its impact on calcium signaling. For their investigation, they isolated primary EO cells from Sprague...

    Subject
    Genomics
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  • NYU Dataset

    FITM2 Deficiency Promotes Hepatic ER Stress in Vitro and in Vivo

    Authors
    Haizhen Wang
    Cyrus Nikain
    Konstantinos I. Fortounas
    Jaume Amengual
    14 more author(s)...
    Description

    This study examined the role of hepatic FITM2, an endoplasmic reticulum (ER) protein, in the partitioning of newly-synthesized triglyceride between the ER, lipid droplets, and nascent very low density lipoprotein (VLDL) particles in vitro and in vivo. The experiments were conducted using a rat hepatic cell line (McA cells) and mice. Effects of FITM2 deficiency on VLDL assembly and secretion in vitro...

    Subject
    Proteomics
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