NYU Data Catalog

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  • NYU Dataset

    Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia

    Authors
    Lucie Bernard-Raichon
    Mericien Venzon
    Jon Klein
    Jordan E. Axelrad
    21 more author(s)...
    Description

    To investigate the relationship between gut microbiome dysbiosis and translocation of bacteria into the blood during SARS-CoV-2 infection in humans, researchers obtained blood culture and stool samples from positive COVID-19 patients who were seen at NYU Langone Health and Yale New Haven Hospital. 67 stool samples were obtained from 60 patients at NYU Langone Health and 63 samples were obtained from...

    Subject
    COVID-19
    Genomics
    Infectious Disease
    Risk Factors
    Timeframe
    2020
    Access Rights
    Free to All
  • NYU Dataset

    Targeting Succinate Receptor Effectively Inhibits Periodontal Disease

    Authors
    Yuqi Guo
    Fangxi Xu
    Scott C. Thomas
    Yanli Zhang
    10 more author(s)...
    Description

    Periodontal disease (PD) is induced by a bacterial dysbiosis in the oral cavity that stimulates inflammation and bone loss. This study showed elevation of succinate in PD, which aggravates the disease through the succinate receptor (SUCNR1). Metabolomics assay compared the succinate level in the subgingival plaque of patients with PD. RNAscope and immunofluorescence assays were conducted to validate...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    SARS-CoV-2 infection and gut microbiome dysbiosis in mice

    Authors
    Lucie Bernard-Raichon
    Mericien Venzon
    Jon Klein
    Jordan E. Axelrad
    21 more author(s)...
    Description

    To investigate the causal relationship between SARS-CoV-2 infection and gut microbiome dysbiosis, researchers inoculated K18-hACE2 male mice with one of four doses (10, 100, 1000, and 104 PFU) of SARS-CoV-2 or mock treatment diluted in phosphate-buffered saline (PBS). Fecal samples were collected from mice daily for microbiome analyses from day 0 (before infection) until sacrifice on days 5–7. Upon...

    Subject
    COVID-19
    Genomics
    Infectious Disease
    Access Rights
    Free to All