NYU Data Catalog

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  • NYU Dataset

    Adipose Tissue Macrophages Adapt to Inflammatory and Metabolic Challenges

    Authors
    Hernandez Moura Silva
    Andre Bafica
    Gabriela Flavia Rodrigues-Luiz
    Jingyi Chi
    13 more author(s)...
    Description

    Adipose tissue macrophages (ATMs) change during metabolic stress and are thought to contribute to metabolic syndrome. This study examined ATM subpopulations in steady state and in response to nutritional and infectious challenges. They characterized the epididymal white adipose tissue (eWAT) lymphoid and myeloid cell populations under steady state using RNA sequencing to analyze the transcriptome of...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Genome-Wide Screening Identifies Trim33 as an Essential Regulator of Dendritic Cell Differentiation

    Authors
    Ioanna Tiniakou
    Pei-Feng Hsu
    Lorena S. Lopez-Zepeda
    Gorkem Garipler
    16 more author(s)...
    Description

    The development of dendritic cells (DCs) are controlled by the growth factor Flt3 ligand (Flt3L) and its receptor Flt3. This study contained in vitro CRISPR/Cas9-based dropout genetic screening of DC differentiation from HoxB8-FL cells, in vitro validation of the inhibition of mammalian target of rapamycin (mTOR) signaling as a requirement for HoxB8-FL differentiation, and in vivo validation of select...

    Subject
    Genomics
    Access Rights
    Free to All