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NYU Dataset
Chemogenic Activation of Interneurons Causes Short-Term and Long-Term Changes in Circuit Dynamics
- Authors
- Stephanie RogersPeter A. RozmanManuel ValeroWerner K. Doyle1 more author(s)...
- Description
Chemogenetic technology designer receptors exclusively activated by designer drugs (DREADD) is a widely used experimental method to control neuronal activity with an exogenous receptor. This study virally expressed an excitatory DREADD in all inhibitory interneuron types of the CA1 region of the hippocampus in the rat. For this study, Sprague Dawley rats were used for viral injection and intracranial...
- Subject
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Neuroscience
- Access Rights
- Free to All
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NYU Dataset
Inhibitory Conductance Controls Place Field Dynamics in the Hippocampus
- Authors
- Manuel ValeroAndrea Navas-OliveLiset M. de la PridaGyorgy Buzsaki
- Description
Place cells receive a disparate collection of excitatory and inhibitory currents that provide them with spatially selective discharges and rhythmic activity. This study combined intracellular and extracellular recordings with computational modeling and optogenetic or chemogenetic manipulations to examine the influence of inhibitory and excitatory inputs on CA1 pyramidal cell responses. Homozygous CaMKIIa-Cre...
- Subject
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Neuroscience
- Access Rights
- Free to All
