NYU Data Catalog

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  • NYU Dataset

    Chemogenic Activation of Interneurons Causes Short-Term and Long-Term Changes in Circuit Dynamics

    Authors
    Stephanie Rogers
    Peter A. Rozman
    Manuel Valero
    Werner K. Doyle
    1 more author(s)...
    Description

    Chemogenetic technology designer receptors exclusively activated by designer drugs (DREADD) is a widely used experimental method to control neuronal activity with an exogenous receptor. This study virally expressed an excitatory DREADD in all inhibitory interneuron types of the CA1 region of the hippocampus in the rat. For this study, Sprague Dawley rats were used for viral injection and intracranial...

    Subject
    Neuroscience
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  • NYU Dataset

    Inhibitory Conductance Controls Place Field Dynamics in the Hippocampus

    Authors
    Manuel Valero
    Andrea Navas-Olive
    Liset M. de la Prida
    Gyorgy Buzsaki
    Description

    Place cells receive a disparate collection of excitatory and inhibitory currents that provide them with spatially selective discharges and rhythmic activity. This study combined intracellular and extracellular recordings with computational modeling and optogenetic or chemogenetic manipulations to examine the influence of inhibitory and excitatory inputs on CA1 pyramidal cell responses. Homozygous CaMKIIa-Cre...

    Subject
    Neuroscience
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  • NYU Dataset

    Oxytocin Induces Embryonic Diapause in Mice

    Authors
    Jessica L. Minder
    Sarah B. Winokur
    Janaye Stephens
    Jie Tong
    14 more author(s)...
    Description

    Through multiple experiments, this study demonstrated that oxytocin induces diapause, a temporary developmental delay, in pre-implantation mouse embryos to help ensure their survival. To assess whether oxytocin receptor (OXTR) signaling might influence this gestational delay, heterozygous (OXTR+/−) dams which retain sufficient OXTR function for apparently normal parturition and nursing, were bred....

    Subject
    Neuroscience
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    Free to All
  • NYU Dataset

    Experience-Dependent Dopamine Modulation of Male Aggression

    Authors
    Bing Dai
    Bingqin Zheng
    Xiuzhi Dai
    Xiaoyang Cui
    7 more author(s)...
    Description

    Aggression is an innate social behaviour that is essential for defending territory, competing for resources, and securing mates. This study demonstrated that dopaminergic cells in the ventral tegmental area (VTA) can bidirectionally modulate aggression in male mice in an experience-dependent manner. To investigate the role of experience-dependent dopamine modulation on aggression, they tested the effect...

    Subject
    Neuroscience
    Access Rights
    Free to All