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NYU Dataset
Sequencing Data Illustrates Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements
- Authors
- Danqi ChenQiao Yi ChenZhenjia WangYusha Zhu12 more author(s)...
- Description
Previous study showed that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histone H3.1 mRNA. This study revealed that polyadenylation of H3.1 mRNA increases H3.1 protein, which results in displacement of histone variant H3.3 at active promoters, enhancers, and insulator regions. To investigate global changes in transcription induced by ectopic expression of polyadenylated...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Gene Expression and Transcription Factors are Modified in Human Keratinocytes Exposed to Solar Simulated Ultraviolet Radiation
- Authors
- Thomas L. Des MaraisThomas KluzDazhong XuXiaoru Zhang4 more author(s)...
- Description
Ultraviolet radiation (UVR) from the sun is the major cause of skin cancer. However, genes and pathways altered by solar-simulated UVR (ssUVR), a mixture of UVA and UVB, still remains unclear. For this study, human HaCaT keratinocytes were exposed to a single dose or 5 repetitive doses of ssUVR. Analyses of gene expression profiles and functional annotation were performed at 24 hours after irradiation....
- Subject
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CancerGenomics
- Access Rights
- Free to All
