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  • NYU Dataset

    Selective Decline of Neurotrophin and Neurotrophin Receptor Genes Discovered From Rush Religious Orders Study

    Authors
    Stephen D. Ginsberg
    Michael H. Malek-Ahmadi
    Melissa J. Alldred
    Shaoli Che
    7 more author(s)...
    Description

    This study profiled neurotrophin and neurotrophin receptor gene expression within microdissected CA1 neurons along with regional hippocampal dissections from participants in the Rush Religious Orders Study (RROS). The RROS participants included older religious clergy who have agreed to medical and psychological evaluation each year and brain donation after death. This study began in 1993 and has enrolled...

    Subject
    Genomics
    Neuroscience
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  • NYU Dataset

    Predictors of Neuritic Plaque and Neurofibrillary Tangle Pathology Determined From Rush Religious Orders Study

    Authors
    Stephen D. Ginsberg
    Michael H. Malek-Ahmadi
    Melissa J. Alldred
    Yinghua Chen
    4 more author(s)...
    Description

    This study investigated whether the Alzheimer’s disease (AD) pathological lesions diffuse plaques (DPs), neuritic plaques (NPs), and neurofibrillary tangles (NFTs). For this study, downregulation of brain-derived neurotrophic factor (BDNF) and its cognate neurotrophin receptor, TrkB, were observed during the progression of dementia. They performed negative binomial (NB) regressions using gene expression...

    Subject
    Neuroscience
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    Author Approval Required
  • NYU Dataset

    GADD34 Promotes Fast Dephosphorylation of eIF2α and Elevation of Neuronal Protein Synthesis

    Authors
    Mauricio M. Oliveira
    Muhaned Mohamed
    Megan K. Elder
    Keylin Banegas-Morales
    7 more author(s)...
    Description

    This study examined the molecular pathways of translational control that are triggered by neuronal stimulation with brain-derived neurotrophic factor (BDNF). For the study, primary rodent neurons were exposed to BDNF and then examined for GADD34 protein levels. GADD34 is a protein phosphatase 1-targeting protein that directly binds to eukaryotic initiation factor 2α (eIF2α). This promotes eIF2α dephosphorylation...

    Subject
    Genomics
    Neuroscience
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