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Results Found: 4
  • NYU Dataset

    Correlation Between Autoimmunity to Phosphatidylserine and Anemia in African Trypanosome Infections

    Authors
    Juan Rivera-Correa
    Joseph Verdi
    Julian Sherman
    Jeremy M. Sternberg
    2 more author(s)...
    Description

    Anemia is a common complication in many infectious diseases, including protozoan parasitic infections. Trypanosomes are eukaryotic parasites and most relevant human trypanosome pathogens are Trypanosoma brucei and Trypanosoma cruzi. Autoimmunity during Trypanosoma brucei infection is indicated to have a role during anemia, but anemia caused by trypanosome infection is poorly understood. In mouse models...

    Subject
    Infectious Disease
    Access Rights
    Free to All
  • NYU Dataset

    Anti-DNA and Anti-Phosphatidylserine Antibodies Predicted Development of Severe COVID-19

    Authors
    Claudia Gomes
    Marisol Zuniga
    Kelly A. Crotty
    Kun Qian
    11 more author(s)...
    Description

    This is a retrospective cohort study of COVID-19 hospitalized patients with different degrees of severity. They performed this study to analyze the generation of autoimmune antibodies to common antigens. This study included 115 hospitalized patients with SARS-CoV-2 infection and 42 uninfected controls. Sample collection was performed as part of routine clinical care for COVID-19 patients at the time...

    Subject
    COVID-19
    Infectious Disease
    Timeframe
    2020
    Access Rights
    Free to All
  • NYU Dataset

    Autoimmunity to Annexin A2 Predicts Mortality Among Hospitalised COVID-19 Patients

    Authors
    Marisol Zuniga
    Claudia Gomes
    Steven E. Carsons
    Michael T. Bender
    4 more author(s)...
    Description

    This study examined autoimmune antibodies to annexin A2, which is a phospholipid-binding protein expressed in the lung and other organs, in COVID-19 patients. Annexin A2 is critical for fibrinolysis, lung elasticity, cell membrane repair, and integrity of the pulmonary vasculature. Therefore, antagonism of annexin A2 may explain many of the clinical features of severe COVID-19 cases. This study analyzed...

    Subject
    COVID-19
    Infectious Disease
    Access Rights
    Application Required
    Author Approval Required
  • NYU Dataset

    Transcription Factor RORα Enforces Stability of the Th17 Cell Effector Program

    Authors
    Jason A. Hall
    Maria Pokrovskii
    Lina Kroehling
    Bo-Ram Kim
    4 more author(s)...
    Description

    The transcription factor RORγt is important for T helper 17 (Th17) cell differentiation. This study examined the role of the closely-related RORα in regulating the Th17 effector program. For the study, mouse T cells were purified from lymph nodes and spleens of six to eight week old mice. The dataset includes RNA sequencing analysis of ex vivo Th17 cells from draining lymph nodes or spinal cords of...

    Subject
    Genomics
    Access Rights
    Free to All