NYU Health Sciences Library NYU Data Catalog
NYU Health Sciences Library NYU Data Catalog
NYU Health Sciences Library Data Catalog

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Results Found: 3
  • NYU Dataset

    Volume Electron Microscopy Reveals Connexin43 in Plakophilin-2 Deficient Hearts

    Authors
    Chantal J. M. van Opbergen
    Joseph Sall
    Christopher Petzold
    Kristen Dancel-Manning
    2 more author(s)...
    Description

    Previous studies showed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. This study combined pre-embedding immunolabeling with serial block-face scanning electron microscopy (SBF-SEM) to visualize and examine the gap junction plaque morphology. They used a murine model of cardiomyocyte-specific Tamoxifen (TAM) activated...

    Subject
    Cell Physiology
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    Author Approval Required
  • NYU Dataset

    Condensation of ORF1p is Critical for LINE-1 Retrotransposition

    Authors
    Srinjoy Sil
    Sarah Keegan
    Farida Ettefa
    Lance T. Denes
    2 more author(s)...
    Description

    Long interspersed element-1 (LINE-1) is an autonomously active retrotransposon in the human genome. The LINE-1 mRNA encodes two proteins, ORF1p and ORF2p, which are essential for retrotransposition. This study showed that electrostatic interactions and trimer conformational dynamics together tune the properties of ORF1p assemblies to allow for efficient LINE-1 ribonucleoprotein complex formation in...

    Subject
    Cell Physiology
    Access Rights
    Free to All
  • NYU Dataset

    Microscopy data associated with manuscript: Cellular interactions in the sentinel lymph node predict melanoma recurrence

    Authors
    Sabrina Solis
    Yang Yang
    Yee Hoon Foong
    Anushka Dheer
    11 more author(s)...
    Description

    In order to understand the immune-spatial environment of melanoma sentinel lymph nodes (SLN), this study profiled 43 tissues samples from a cohort Stage II melanoma that underwent SLN biopsy. All samples were randomly selected from archived samples between 2010-2017 at the University of Pennsylvania. The median age of the cohort was 61 and 76% were male. 22 lacked tumor infiltration (SLN-) 21 contained...

    Subject
    Anatomy
    Cancer
    Cell Physiology
    Proteomics
    Access Rights
    Free to All