Chronic Kidney Disease in Children
Alternate Titles(s): CKiD
- Description
The Chronic Kidney Disease in Children (CKiD) Study is a multicenter, observational, prospective cohort study of children, adolescents, and young adults with a history of mild to moderately impaired kidney function. The primary goals of the study are to determine the risk factors for decline in kidney function, how a progressive decline in kidney function impacts neurocognitive function and behavior, risk factors for cardiovascular disease, and associations between growth failure and morbidity. CKiD began in 2003 and has enrolled four cohorts, totaling over 1000 participants across the United States and Canada.
At baseline, participants underwent a physical examination, and data were collected on kidney, cardiovascular, and neurocognitive symptoms and function, as well as information on demographics, medications, genetics, and growth. Biospecimens, including serum, plasma, and urine, are also collected. Similar measures are assessed at annual follow-ups. The primary outcome measure is the rate of decline of glomerlular filtration rate (GFR). Participants are followed through their initiation of dialysis or transplant in order to more fully understand the course of the disease and the population’s health beyond kidney replacement therapy (KRT). Data are also collected on important clinical events, such as the onset of end-stage kidney disease, that are particularly meaningful to the population.- Publisher
- Timeframe
- 2003 - Present
- Geographic Coverage
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AlabamaArizonaCaliforniaCanadaColoradoSee all...DelawareFloridaGeorgiaIllinoisIndianaMarylandMassachusettsMichiganMissouriNew JerseyNew MexicoNew York (State)North CarolinaOhioOklahomaOregonTennesseeTexasUnited StatesVirginiaWashington (State)Washington, D.C.Wisconsin
- Local Expert
Access
- Restrictions
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Application Required
- Instructions
Baseline and follow-up biospecimens and data through April 30, 2022 are available for request through the NIDDK Central Repository. Users will be required to log in with their NIH Researcher Authorization Service (RAS) credentials in order to request access.
All other data and specimens are available for request directly through CKiD. External investigators are required to discuss their research proposal with a CKiD liaison, submit a concept sheet, and complete a Data Use Agreement.
- PubMed Search
- View articles which use this dataset
- Other Resources
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Documentation
CKiD summary files, data collection forms, and codebooks
CKiD CalculatorsUnder 25 GFR estimating equations
ClinicalTrials.govNCT00327860