Development of Long-Term Vagus Nerve Stimulation in Mouse Model
- Description
This study developed a scalable model for long-term vagus nerve stimulation (VNS) in mice. Male C57BL/6 mice were instrumented with implanted ECG electrodes to measure heart rate threshold in conscious animals. In awake experiments, animals implanted with ECG leads were gently restrained and connected to a commutator that interfaced with the stimulus generator and the bio-amplifier. The dataset includes source data that was used to assemble different figures in the publication. Source data contains data on heart rate measurements at baseline and during VNS at different intensities, pre-implantation and longitudinal impedance and heart rate threshold values, and heart rate and blood pressure changes after phenylephrine injection used to calculate baroreflex sensitivity index. This model provides a tool to systematically investigate long-term VNS as therapy for chronic diseases modeled in mice.
Access
- Restrictions
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Free to All
- Instructions
- All data generated or analyzed during this study are available within the article on PubMed Central (PMC).
- Grant Support
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HHMI Faculty Scholars/Howard Hughes Medical InstituteHR0011-17-2-0025/Defense Advanced Research Projects AgencyHR0011-17-2-0051/Defense Advanced Research Projects AgencyN66001-17-2-4010/Defense Advanced Research Projects AgencyUnited Therapeutics Corporation/United Therapeutics CorporationBoston Scientific/Boston Scientific