Development of Long-Term Vagus Nerve Stimulation in Mouse Model
- Description
This study developed a scalable model for long-term vagus nerve stimulation (VNS) in mice. For this study, C57BL/6 mice were used in all experiments. The dataset includes histology and immunohistochemistry data as well as supplementary data tied to the publication. The supplementary data includes data that was used to assemble different figures in the publication, which contains data about heart rate measurements at baseline and during VNS at different intensities, pre-implantation and longitudinal impedance and heart rate threshold values, and heart rate and blood pressure changes after phenylephrine injection used to calculate baroreflex sensitivity index. This model provides a tool to systematically investigate long-term VNS as therapy for chronic diseases modeled in mice.
Access
- Restrictions
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Free to All
- Instructions
- All data generated or analyzed during this study are included in the manuscript and supporting files on PubMed Central (PMC).
- Grant Support
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HHMI Faculty Scholars/Howard Hughes Medical InstituteHR0011-17-2-0025/Defense Advanced Research Projects AgencyHR0011-17-2-0051/Defense Advanced Research Projects AgencyN66001-17-2-4010/Defense Advanced Research Projects AgencyUnited Therapeutics Corporation/United Therapeutics CorporationBoston Scientific/Boston Scientific