The Type 1 Diabetes (T1D) Exchange Clinic Registry collects information on individuals with type 1 diabetes from participating institutions in the United States in order to help researchers characterize individuals living with the disease, conduct exploratory or hypothesis-generating analyses, and identify potential participants for future clinical studies. The registry includes over 26,000 individuals with T1D, ranging in age at the time of enrollment from under 1 year to 93 years. Variables collected for the T1D Exchange Clinic Registry include demographic information, treatment history, family health history, levels of physical activity, smoking status, history of seizures, and total daily insulin.

De-identified datasets derived from the T1D Exchange Registry are available through the Jaeb Center for Health Research (JCHR), including 'Severe Hypoglycemia in Older Adults with Type 1 Diabetes,' 'Metformin Therapy for Overweight Adolescents with T1D,' and 'T1D Management Study.' New and ongoing research is being conducted through the T1D Exchange Quality Improvement Collaborative.