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NYU Dataset
Structure Prediction Modeling Characterized Guided Entry of Tail-Anchored Proteins 3 in Mycobacterium tuberculosis
- Authors
- Kuan HuAshley JordanSusan ZhangAvantika Dhabaria5 more author(s)...
- Description
This study investigated the pathways important for Mycobacterium tuberculosis (M. tuberculosis) pathogenesis. M. tuberculosis genome was searched for open reading frames and an operon, Rv3679-Rv3680, was identified. Using structure prediction modeling, they found that Rv3679 and Rv3680 have some structural similarity to the guided entry of tail-anchored proteins 3, which delivers proteins into the...
- Subject
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Infectious DiseaseProteomics
- Access Rights
- Free to All
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NYU Dataset
Depupylase Dop Regulates Substrate Selectivity in Mycobacterium tuberculosis
- Authors
- Jin Hee YooShoshanna C. KahneK. Heran Darwin
- Description
Mycobacteria encode a prokaryotic ubiquitin-like protein that posttranslationally modifies proteins to mark them for proteolysis. Pupylation occurs on lysines of targeted proteins and is catalyzed by the ligase PafA. Like ubiquitylation, pupylation can be reversed by the depupylase Dop, which shares high structural similarity with PafA. Unique to Dop near its active site is a disordered loop of approximately...
- Subject
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Infectious DiseaseProteomics
- Access Rights
- Free to All