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NYU Dataset
FITM2 Deficiency Promotes Hepatic ER Stress in Vitro and in Vivo
- Authors
- Haizhen WangCyrus NikainKonstantinos I. FortounasJaume Amengual14 more author(s)...
- Description
This study examined the role of hepatic FITM2, an endoplasmic reticulum (ER) protein, in the partitioning of newly-synthesized triglyceride between the ER, lipid droplets, and nascent very low density lipoprotein (VLDL) particles in vitro and in vivo. The experiments were conducted using a rat hepatic cell line (McA cells) and mice. Effects of FITM2 deficiency on VLDL assembly and secretion in vitro...
- Subject
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Proteomics
- Access Rights
- Application RequiredAuthor Approval Required
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NYU Dataset
Human Hepatoma Huh-7 Cell Culture Models Deficient in Apolipoprotein B Secretion
- Authors
- Swati ValmikiSara RosarioAshley MooringChandana Prakashmurthy7 more author(s)...
- Description
Apolipoprotein B (apoB) is an essential structural protein for the assembly and secretion of triglyceride-rich lipoproteins. Inhibition of apoB and microsomal triglyceride transfer protein (MTP) decreases plasma lipid levels but at a risk of lipid accumulation in tissues. To understand the global consequences of APOB gene deficiency, a human hepatoma (Huh-7) cell culture model system deficient in apoB...
- Subject
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Genomics
- Access Rights
- Free to All