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NYU Dataset
Synaptic Vesicle Traffic is Supported by Transient Actin Filaments
- Authors
- Nicolas ChenouardFeng XuanRichard W. Tsien
- Description
Synaptic vesicles (SVs) play a key role in synaptic transmission. This study used time-lapse microscopy to demonstrate two distinct mechanisms of vesicle traffic along axons. They utilized specific pharmacological interventions along with imaging of transient actin polymerization, and traffic of recycling SVs loaded with single quantum dots to characterize the underlying axonal actin structures. For...
- Subject
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Neuroscience
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- Application RequiredAuthor Approval Required
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NYU Dataset
Cortical Neuron Firing Patterns, Synaptic Connectivity, and Plasticity to Task Performance
- Authors
- Michele N. InsanallyBadr F. AlbannaJade TothBrian DePasquale6 more author(s)...
- Description
This study investigated the synaptic basis for various types of spiking response profiles, and how synaptic plasticity learning rules are important for shaping synaptic inputs for spike output and network performance. They leveraged cell-attached, extracellular, and whole-cell recordings from behaving animals alongside recurrent network modeling to explore the synaptic origins and functional contribution...
- Subject
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Neuroscience
- Access Rights
- Free to All
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NYU Dataset
Impairment of Visual Cortical Plasticity by Amyloid-Beta Species
- Authors
- Christopher M. WilliamMatthew A. SternXuewei PeiLubna Saqran3 more author(s)...
- Description
Alzheimer’s disease (AD) is characterized by accumulation of amyloid-beta (Aβ) in amyloid plaques and transgenic and knock-in mice that express mutant alleles of amyloid precursor protein (APP) have been used to model the effects of Aβ. This study examined visual system plasticity in transgenic mice that express and secrete Aβ throughout the brain in the absence of APP overexpression to explore the...
- Subject
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Neuroscience
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- Application RequiredAuthor Approval Required