NYU Health Sciences Library NYU Data Catalog
NYU Health Sciences Library NYU Data Catalog
NYU Health Sciences Library Data Catalog

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Results Found: 3
  • NYU Dataset

    Synaptic Vesicle Traffic is Supported by Transient Actin Filaments

    Authors
    Nicolas Chenouard
    Feng Xuan
    Richard W. Tsien
    Description

    Synaptic vesicles (SVs) play a key role in synaptic transmission. This study used time-lapse microscopy to demonstrate two distinct mechanisms of vesicle traffic along axons. They employed specific pharmacological interventions along with imaging of transient actin polymerization and traffic of recycling SVs loaded with single quantum dots to characterize the underlying axonal actin structures. For...

    Subject
    Neurosciences
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    Application Required
    Author Approval Required
  • NYU Dataset

    Cortical Neuron Firing Patterns, Synaptic Connectivity, and Plasticity to Task Performance

    Authors
    Michele N. Insanally
    Badr F. Albanna
    Jade Toth
    Brian DePasquale
    6 more author(s)...
    Description

    This study investigated the synaptic basis for various types of spiking response profiles, and how synaptic plasticity learning rules are important for shaping synaptic inputs for spike output and network performance. They leveraged cell-attached, extracellular, and whole-cell recordings from behaving animals alongside recurrent network modeling to explore the synaptic origins and functional contribution...

    Subject
    Neurosciences
    Access Rights
    Free to All
  • NYU Dataset

    Synaptic Homeostasis Transiently Leverages Hebbian Mechanisms for a Multiphasic Response to Inactivity

    Authors
    Simon(e) D. Sun
    Daniel Levenstein
    Boxing Li
    Nataniel Mandelberg
    7 more author(s)...
    Description

    Synaptic plasticity is assumed to be a key biological substrate of learning, memory, and neural circuit development. Two forms of plasticity are thought to enable neurons to integrate recent activity changes without veering into extreme hypoactivity or hyperactivity. This includes Hebbian positive feedback to strengthen active synapses, long-term potentiation(LTP), and diminish less active ones, long-term...

    Subject
    Neurosciences
    Access Rights
    Free to All