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  • NYU Dataset

    Targeting Succinate Receptor Effectively Inhibits Periodontal Disease

    Authors
    Yuqi Guo
    Fangxi Xu
    Scott C. Thomas
    Yanli Zhang
    10 more author(s)...
    Description

    Periodontal disease (PD) is induced by a bacterial dysbiosis in the oral cavity that stimulates inflammation and bone loss. This study showed elevation of succinate in PD, which aggravates the disease through the succinate receptor (SUCNR1). Metabolomics assay compared the succinate level in the subgingival plaque of patients with PD. RNAscope and immunofluorescence assays were conducted to validate...

    Subject
    Genomics
    Access Rights
    Free to All