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  • NYU Dataset

    Staphylococcus Aureus Cell Envelope Selectively Controls the Sorting of Selective Exoproteins

    Authors
    Xuhui Zheng
    Gerben Marsman
    Keenan A. Lacey
    Jessica R. Chapman
    3 more author(s)...
    Description

    Leukocidins are crucial components of Staphylococcus aureus (S. aureus) and they are secreted toxins that directly target and lyse immune cells. One of the leukocidins, Leukocidin AB (LukAB), is associated with the bacterial cell envelope. This study examined how S. aureus regulates LukAB secretion as well as the role of bacteria-associated LukAB in host-pathogen interaction. Using tissue culture models...

    Subject
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Unlatching of the Stem Domains in the Staphylococcus Aureus Leukocidin LukAB Influences Toxin Oligomerization

    Authors
    Juliana K. Ilmain
    Sofya S. Perelman
    Maria C. Panepinto
    Irnov Irnov
    7 more author(s)...
    Description

    Staphylococcus aureus is a pathogen that utilizes a family of pore-forming toxins, leukocidins, to evade the host immune response and promote infection. Among these is leukocidin AB (LukAB), which engages host receptors to initiate pore formation on the host cell. The established cellular receptor for LukAB is CD11b. This study intoxicated CD11b-deficient cells with an alanine scanning library of CC8...

    Subject
    Proteomics
    Access Rights
    Free to All