NYU Dataset
Staphylococcus Aureus Cell Envelope Selectively Controls the Sorting of Selective Exoproteins
Part of: Torres Lab |
UID: 10568
- Description
Leukocidins are crucial components of Staphylococcus aureus (S. aureus) and they are secreted toxins that directly target and lyse immune cells. One of the leukocidins, Leukocidin AB (LukAB), is associated with the bacterial cell envelope. This study examined how S. aureus regulates LukAB secretion as well as the role of bacteria-associated LukAB in host-pathogen interaction. Using tissue culture models of infection, they investigated whether the localization of LukAB on the bacterial cells contributes to S. aureus-mediated killing of primary human neutrophils. The dataset contains immunofluorescence imaging and mass spectrometry data. In addition, the publication includes source data for underlying figures.
Staphylococcus aureus
Polymorphonuclear leukocytes
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
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Free to All
- Instructions
- The mass spectrometric raw data generated in this study are accessible from the MassIVE database. The exoprotein mass spectrometry data were obtained from the MassIVE database and the nucleotide sequences of genes were acquired from GenBank through NCBI Nucleotide database. Source data are provided with this paper on PubMed Central (PMC).
RMC MT-X Ultramicrotome
SpeedVac
- Grant Support
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Max Planck Society for the Advancement of Science/Max Planck Society for the Advancement of ScienceBurroughs Wellcome Fund/Burroughs Wellcome FundCystic Fibrosis Postdoctoral Research Fellowship/Cystic Fibrosis Foundation
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