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  • NYU Dataset

    CpG Oligodeoxynucleotides Improves Alzheimer’s Disease Pathology in Aged Squirrel Monkeys

    Authors
    Akash G. Patel
    Pramod N. Nehete
    Sara R. Krivoshik
    Xuewei Pei
    7 more author(s)...
    Description

    Previous studies showed that harnessing innate immunity via CpG oligodeoxynucleotides (ODNs) modulates age-related defects. This study used elderly female squirrel monkeys as model of sporadic Alzheimer’s disease pathology. Current immunotherapeutic trials for Alzheimer’s disease have amyloid-related imaging flaws, which are linked to the presence of cerebral amyloid angiopathy (CAA). Therefore, the...

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