NYU Data Catalog

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  • NYU Dataset

    Intra-axonal Space Segmentation from 3D Scanning Electron Microscopy (SEM) of the Mouse Brain Genu of Corpus Callosum

    Authors
    Hong-Hsi Lee
    Dmitry S. Novikov
    Els Fieremans
    Description

    This dataset includes 3D scanning electron microscopy (SEM) images of a female mouse corpus callosum and MATLAB code for random walker (RaW) segmentations of myelinated axons. The code additionally characterizes inner axonal diameters and fiber orientation dispersion within segments of the intra-axonal spaces and myelin sheaths. In the study, a female 8-week-old C57BL/6 mouse was perfused trans-cardiacally...

    Subject
    Anatomy
    Neuroscience
    Access Rights
    Free to All
  • NYU Dataset

    Volume Electron Microscopy Reveals Connexin43 in Plakophilin-2 Deficient Hearts

    Authors
    Chantal J. M. van Opbergen
    Joseph Sall
    Christopher Petzold
    Kristen Dancel-Manning
    2 more author(s)...
    Description

    Previous studies showed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. This study combined pre-embedding immunolabeling with serial block-face scanning electron microscopy (SBF-SEM) to visualize and examine the gap junction plaque morphology. They used a murine model of cardiomyocyte-specific Tamoxifen (TAM) activated...

    Subject
    Cell Physiology
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    Application Required
    Author Approval Required
  • NYU Dataset

    3D Reconstructions of Parasite Development and the Intracellular Niche of Encephalitozoon intestinalis

    Authors
    Noelle V. Antao
    Cherry Lam
    Ari Davydov
    Margot Riggi
    6 more author(s)...
    Description

    Microsporidia are obligate intracellular pathogens that infect a wide range of invertebrate and vertebrate hosts, including humans. In humans, microsporidia most often infect the gastrointestinal tract and cause diarrheal diseases, but in immunocompromised patients, infections can be fatal. Previous knowledge of microsporidian intracellular development was based on 2D transmission electron microscopy...

    Subject
    Infectious Disease
    Access Rights
    Free to All
  • NYU Dataset

    Energetics of the Microsporidian Polar Tube Invasion Machinery

    Authors
    Ray Chang
    Ari Davydov
    Pattana Jaroenlak
    Breane Budaitis
    3 more author(s)...
    Description

    Microsporidia are obligate intracellular parasites that use an unusual invasion organelle called the polar tube (PT), which is ejected from a dormant spore at ultra-fast speeds, to infect host cells. This study used serial block-face scanning electron microscopy (SBF-SEM) to capture 3-dimensional snapshots of Anncaliia algerae spores in different states of the PT ejection process. They proposed a theoretical...

    Subject
    Infectious Disease
    Access Rights
    Free to All