NYU Data Catalog

Filter by

of 1 Next >
Results Found: 1
  • NYU Dataset

    Condensation of ORF1p is Critical for LINE-1 Retrotransposition

    Authors
    Srinjoy Sil
    Sarah Keegan
    Farida Ettefa
    Lance T. Denes
    2 more author(s)...
    Description

    Long interspersed element-1 (LINE-1) is an autonomously active retrotransposon in the human genome. The LINE-1 mRNA encodes two proteins, ORF1p and ORF2p, which are essential for retrotransposition. This study showed that electrostatic interactions and trimer conformational dynamics together tune the properties of ORF1p assemblies to allow for efficient LINE-1 ribonucleoprotein complex formation in...

    Subject
    Cell Physiology
    Access Rights
    Free to All