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NYU Dataset
Sequencing Data Illustrates Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements
- Authors
- Danqi ChenQiao Yi ChenZhenjia WangYusha Zhu12 more author(s)...
- Description
Previous study showed that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histone H3.1 mRNA. This study revealed that polyadenylation of H3.1 mRNA increases H3.1 protein, which results in displacement of histone variant H3.3 at active promoters, enhancers, and insulator regions. To investigate global changes in transcription induced by ectopic expression of polyadenylated...
- Subject
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Genomics
- Access Rights
- Free to All
