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  • NYU Dataset

    Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

    Authors
    Bryan Ngo
    Eugenie Kim
    Victoria Osorio-Vasquez
    Sophia Doll
    36 more author(s)...
    Description

    Brain metastasis is the most common intracranial malignancy in adults, which is often fatal. Studies have shown that brain metastases depend on cooperative cellular interactions between tumor cells and specialized cells within the central nervous system (CNS). Metabolic constraints imposed by the serine and glycine limited brain environment restrict metastatic tumor growth. This study showed that 3-phosphoglycerate...

    Subject
    Neuroscience
    Proteomics
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