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NYU Dataset
Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs Requires SHMT2
- Authors
- Denise R. MintonMinwoo NamDaniel J. McLaughlinJong Shin7 more author(s)...
- Description
Eukaryotic cells upregulate oxidative metabolism to maintain homeostasis upon glucose restriction. This study used CRISPR/Cas9-based screening to identify serine catabolic enzyme SHMT2. They found that the mitochondrial SHMT2 is required for robust mitochondrial oxygen consumption and low glucose proliferation. This dataset contains immunoblot images, as well as supplementary data tied to the publication....
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
NFS1 Undergoes Positive Selection in Lung Tumors and Protects Cells from Ferroptosis
- Authors
- Samantha W. AlvarezVladislav O. SviderskiyErdem M. TerziThales Papagiannakopoulos5 more author(s)...
- Description
This study performed loss-of-function screens in a transformed breast cell line using a metabolism-restricted short hairpin RNA (shRNA) library to understand differences in metabolic pathway requirements between in vitro model systems and in vivo tumors. They found that cancer cells depend on high levels of the iron–sulfur cluster biosynthetic enzyme NFS1. This dataset includes supplementary data tied...
- Subject
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Genomics
- Access Rights
- Free to All
