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NYU Dataset
Targeting of Intracellular Oncoproteins with Peptide-Centric Chimeric Antigen Receptors
- Authors
- Mark YarmarkovichQuinlen F. MarshallJohn M. WarringtonRasika Premaratne24 more author(s)...
- Description
This study demonstrated that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis. They targeted the unmutated peptide QYNPIRTTF discovered on HLA-A*24:02, which is derived from the neuroblastoma-dependency gene and master transcriptional regulator PHOX2B. To target QYNPIRTTF, they developed peptide-centric chimeric antigen receptors (PC-CARs)...
- Subject
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CancerProteomics
- Access Rights
- Free to All
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NYU Dataset
Proximity Labeling Identifies BIRC6 as a Ubiquitin Ligase for KRAS4A
- Authors
- Juan Kochen RossiCristina Nuevo-TapiolesRachel A. O’KeefeMoritz Hunkeler11 more author(s)...
- Description
KRAS is a frequently mutated oncogene in human cancers and a critical driver of high-mortality cancers such as lung, colon, and pancreatic adenocarcinoma. Recent advances in drug design have led to the development of multiple strategies to inactivate KRAS. Therefore, this study performed proximity labeling to map the differential interactomes of the KRAS splice variants, KRAS4A and KRAS4B. Among the...
- Subject
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CancerProteomics
- Access Rights
- Free to All