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  • NYU Dataset

    Targeting of Intracellular Oncoproteins with Peptide-Centric Chimeric Antigen Receptors

    Authors
    Mark Yarmarkovich
    Quinlen F. Marshall
    John M. Warrington
    Rasika Premaratne
    24 more author(s)...
    Description

    This study demonstrated that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis. They targeted the unmutated peptide QYNPIRTTF discovered on HLA-A*24:02, which is derived from the neuroblastoma-dependency gene and master transcriptional regulator PHOX2B. To target QYNPIRTTF, they developed peptide-centric chimeric antigen receptors (PC-CARs)...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All