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  • NYU Dataset

    An eIF3d-Dependent Switch Regulates Human Cytomegalovirus Replication

    Authors
    Letitia Thompson
    Daniel P. Depledge
    Hannah M. Burgess
    Ian Mohr
    Description

    Gene expression rapidly responds to physiological stress like virus infection in part via the control of mRNA translation. However, how translation of virus and host mRNAs are regulated during infection stress remains unknown. This study showed that protein synthesis in human cytomegalovirus (HCMV)-infected cells unexpectedly becomes progressively reliant upon eIF3d, which is a mRNA cap-binding protein...

    Subject
    Genomics
    Access Rights
    Free to All