NYU Data Catalog

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  • NYU Dataset

    Structural Basis of Ion-Substrate Coupling in the Sodium-Dependent Dicarboxylate Transporter VcINDY

    Authors
    David B. Sauer
    Jennifer J. Marden
    Joseph C. Sudar
    Jinmei Song
    2 more author(s)...
    Description

    VcINDY is a sodium-dependent dicarboxylate transporter that imports tricarboxylic acid cycle intermediates across the inner membrane of Vibrio cholerae. This study used a combination of structure determination by single-particle cryo-electron microscopy, substrate-binding affinity measurements by intrinsic tryptophan fluorescence quenching, and position accessibility quantification by site-directed...

    Subject
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Energy Coupling and Stoichiometry of Zn2+/H+ Antiport by YiiP

    Authors
    Adel Hussein
    Shujie Fan
    Maria Lopez-Redondo
    Ian Kenney
    3 more author(s)...
    Description

    Previous studies of YiiP, bacterial Zn2+/H+ antiporter, have shown a homodimeric architecture and the presence of three distinct Zn2+ binding sites. YiiP is a representative of the cation diffusion facilitator superfamily, which are responsible for homeostasis of transition metal ions. This study used cryo-electron microscopy, microscale thermophoresis, and molecular dynamics simulations to address...

    Subject
    Proteomics
    Access Rights
    Free to All