NYU Data Catalog

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  • NYU Dataset

    Novel pH Modulation of Lysosomes Through β2-Adrenergic Regulation of ClC-7 in Alzheimer’s Disease

    Authors
    Ju-Hyun Lee
    Devin M. Wolfe
    Sandipkumar Darji
    Mary Kate McBrayer
    5 more author(s)...
    Description

    Lysosomal dysfunction plays a key role in the pathogenesis of Alzheimer’s disease and Parkinson’s disease. In early onset of Alzheimer’s disease, there is loss of Presenilin-1 (PSEN1) function. The loss of PSEN1 function interferes with ER to lysosome delivery of chloride channel-7. For this study, isoproterenol and related β2-adrenergic agonists was used to reverse lysosomal chloride deficits in murine...

    Subject
    Genomics
    Neuroscience
    Access Rights
    Free to All
  • NYU Dataset

    Lysosomal Dysfunction in Down Syndrome is APP-Dependent and Mediated by APP-βCTF

    Authors
    Ying Jiang
    Yutaka Sato
    Eunju Im
    Martin J. Berg
    8 more author(s)...
    Description

    Lysosomal failure plays an important role in the pathogenesis of many congenital neurodegenerative disorders, such as Alzheimer’s disease (AD) and Down syndrome (DS). This study showed that lysosomal dysfunction in DS requires the extra gene copy of amyloid precursor protein (APP) and is specifically mediated by the β cleaved carboxy terminal fragment of APP (APP-βCTF). In primary fibroblasts from...

    Subject
    Genomics
    Neuroscience
    Access Rights
    Free to All