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  • NYU Dataset

    KEAP1 Mutation in Lung Adenocarcinoma Promotes Immune Evasion and Immunotherapy Resistance

    Authors
    Anastasia-Maria Zavitsanou
    Ray Pillai
    Yuan Hao
    Warren L. Wu
    23 more author(s)...
    Description

    Lung cancer is the leading cause of cancer related deaths worldwide and immunotherapy has become an important therapeutic intervention. Immunotherapy for lung cancer patients often fails with specific mutations like KEAP1. This study examined the impact of KEAP1 mutations on cancer growth and immune surveillance. They generated an orthotopic transplant model of KrasG12D/+; p53-/- lung cancer with cells...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All