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  • NYU Dataset

    Brain Insulin Resistance in Subjects with Major Depressive Disorder

    Authors
    Carla Nasca
    Josh Dobbin
    Benedetta Bigio
    Kathleen Watson
    9 more author(s)...
    Description

    Previous studies in rodent showed impaired brain insulin signaling with resultant insulin resistance (IR) modulates synaptic plasticity and the corresponding behavioral functions. This study investigated whether brain enriched exosomes and brain IR differ between subjects with major depressive disorder (MDD) and respective controls. They also examined potential sex differences in circulating brain...

    Subject
    Neuroscience
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  • NYU Dataset

    Acetyl-L-Carnitine Deficiency in Patients with Major Depressive Disorder

    Authors
    Carla Nasca
    Benedetta Bigio
    Francis S. Lee
    Sarah P. Young
    9 more author(s)...
    Description

    This study identified biological targets in major depressive disorder (MDD). Acetyl-l-carnitine (LAC), which is critical for hippocampal function and several behavioral domains, has rapid and enduring antidepressant like effects in LAC deficient rodents. As a result, this study examined LAC levels in humans. Following an initial phone screen, potential participants were evaluated in person to determine...

    Subject
    Neuroscience
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    Author Approval Required