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  • NYU Dataset

    Cardiac Muscle–Restricted Partial Loss of Nos1ap Expression Has Limited Impact on Electrocardiographic Features

    Authors
    Alexa Smith
    Dallas Auer
    Morgan Johnson
    Ernesto Sanchez
    4 more author(s)...
    Description

    Previous studies in murine cardiomyocytes and ex vivo knockdown in zebrafish embryonic hearts have demonstrated that NOS1AP expression levels can alter cellular electrophysiology. Therefore, this study generated constitutive and heart muscle-restricted Nos1ap knockout mice to explore the role of NOS1AP in cardiac electrophysiology and QT interval regulation in vivo. To assess the impact of Nos1ap loss...

    Subject
    Genomics
    Access Rights
    Free to All