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NYU Dataset
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
- Authors
- Bryan NgoEugenie KimVictoria Osorio-VasquezSophia Doll36 more author(s)...
- Description
Brain metastasis is the most common intracranial malignancy in adults, which is often fatal. This study showed that 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the rate limiting step of glucose derived serine synthesis, is a major determinant of brain metastasis. For the study, proteomes and labeled metabolomes of parental, aggressive, and indolent TNBC brain metastatic (BrM) cells were...
- Subject
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NeurosciencesProteomics
- Access Rights
- Application RequiredAuthor Approval Required