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  • NYU Dataset

    High-Resolution Fluorescence-Guided Transcranial Ultrasound Mapping in the Live Mouse Brain

    Authors
    Hector Estrada
    Justine Robin
    Ali Ozbek
    Zhenyue Chen
    7 more author(s)...
    Description

    Studying the physiological impact of transcranial ultrasound in rodent brains may offer an important preclinical model for human scale magnetic resonance-guided focused ultrasound methods. Therefore, this study found a versatile bidirectional hybrid fluorescence-ultrasound system with a fiberscope-based wide-field fluorescence imaging. This dataset contains functional connectivity data. The functional...

    Subject
    Neuroscience
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  • NYU Dataset

    Structural Basis of Ion-Substrate Coupling in the Sodium-Dependent Dicarboxylate Transporter VcINDY

    Authors
    David B. Sauer
    Jennifer J. Marden
    Joseph C. Sudar
    Jinmei Song
    2 more author(s)...
    Description

    VcINDY is a sodium-dependent dicarboxylate transporter that imports tricarboxylic acid cycle intermediates across the inner membrane of Vibrio cholerae. This study used a combination of structure determination by single-particle cryo-electron microscopy, substrate-binding affinity measurements by intrinsic tryptophan fluorescence quenching, and position accessibility quantification by site-directed...

    Subject
    Proteomics
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  • NYU Dataset

    Dietary Thiols Accelerates Aging of Caenorhabditis elegans

    Authors
    Ivan Gusarov
    Ilya Shamovsky
    Bibhusita Pani
    Laurent Gautier
    5 more author(s)...
    Description

    Glutathione (GSH) and its precursor, N-acetylcysteine (NAC), are common thiol antioxidants, which are among the most popular dietary supplements. However, the long-term effects of GSH or NAC on healthy animals have not been properly studied. This study examined the effects of prolonged supplementation and chronic restriction of GSH and NAC on Caenorhabditis elegans physiology and lifespan. For RNA...

    Subject
    Genomics
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  • NYU Dataset

    Condensation of ORF1p is Critical for LINE-1 Retrotransposition

    Authors
    Srinjoy Sil
    Sarah Keegan
    Farida Ettefa
    Lance T. Denes
    2 more author(s)...
    Description

    Long interspersed element-1 (LINE-1) is an autonomously active retrotransposon in the human genome. The LINE-1 mRNA encodes two proteins, ORF1p and ORF2p, which are essential for retrotransposition. This study showed that electrostatic interactions and trimer conformational dynamics together tune the properties of ORF1p assemblies to allow for efficient LINE-1 ribonucleoprotein complex formation in...

    Subject
    Cell Physiology
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  • NYU Dataset

    Subcellular Population Imaging Tools Reveal Stable Apical Dendrites in Hippocampal Area CA3

    Authors
    Jason J. Moore
    Shannon K. Rashid
    Emmett Bicker
    Cara D. Johnson
    3 more author(s)...
    Description

    This study imaged in vivo calcium signals from soma, apical dendrites, and basal dendrites in mouse hippocampal CA3 pyramidal neurons during head-fixed navigation to demonstrate apical and basal dendrites of pyramidal neurons receive anatomically and functionally distinct inputs. Computational tools were developed to automatically segment dendrites and extract accurate fluorescence traces from densely...

    Subject
    Neuroscience
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    Free to All