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  • NYU Dataset

    GADD34 Promotes Fast Dephosphorylation of eIF2α and Elevation of Neuronal Protein Synthesis

    Authors
    Mauricio M. Oliveira
    Muhaned Mohamed
    Megan K. Elder
    Keylin Banegas-Morales
    7 more author(s)...
    Description

    This study examined the molecular pathways of translational control that are triggered by neuronal stimulation with brain-derived neurotrophic factor (BDNF). For the study, primary rodent neurons were exposed to BDNF and then examined for GADD34 protein levels. GADD34 is a protein phosphatase 1-targeting protein that directly binds to eukaryotic initiation factor 2α (eIF2α). This promotes eIF2α dephosphorylation...

    Subject
    Genomics
    Neuroscience
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