NYU Data Catalog

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  • NYU Dataset

    ORF2p Eludes Detection in Mass Spectrometry-Based Tumor Proteome Profiling

    Authors
    Daniel Ardeljan
    Xuya Wang
    Mehrnoosh Oghbaie
    Martin S. Taylor
    15 more author(s)...
    Description

    This study showed that long interspersed element-1 (LINE-1) ORF2p expression is almost undetectable in human cancers. LINE-1 is the major driver of mobile DNA activity in humans. When expressed, LINE-1 loci produce bicistronic transcripts encoding two proteins essential for retrotransposition, ORF1p and ORF2p. ORF2p expression is not well characterized in human tissues and cell lines. For the study,...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Structural Characterization of Monoclonal Antibodies Targeting Ser404 Region of Phosphorylated Tau Protein

    Authors
    Jessica E. Chukwu
    Erin E. Congdon
    Einar M. Sigurdsson
    Xiang-Peng Kong
    Description

    Tau is one of the major microtubule-associated proteins in neurons. Its main role is to stabilize microtubules, supporting cytoskeletal organization, and axonal transport. Tau may undergo pathological modifications and become hyperphosphorylated. This causes the protein to accumulate into toxic assemblies that collectively lead to neurodegeneration. In Alzheimer's disease, tau proteins change shape...

    Subject
    Neuroscience
    Proteomics
    Access Rights
    Free to All