NYU Data Catalog

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  • NYU Dataset

    PRC1 Sustains the Integrity of Neural Fate in the Absence of PRC2 Function

    Authors
    Ayana Sawai
    Sarah Pfennig
    Milica Bulajic
    Alexander Miller
    3 more author(s)...
    Description

    Polycomb repressive complexes (PRCs) are known for repressing transcription through histone modifications and chromatin compaction. The PRCs consist of two central protein complexes, PRC1 and PRC2, which are important for normal gene regulation and development. This study found that PRC1 is essential for the specification of segmentally restricted spinal motor neuron subtypes, while PRC2 activity is...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Foxa2 and Pet1 Direct and Indirect Synergy Drive Serotonergic Neuronal Differentiation

    Authors
    Begum Aydin
    Michael Sierk
    Mireia Moreno-Estelles
    Link Tejavibulya
    4 more author(s)...
    Description

    Transcription factors (TFs) are the key players controlling transcriptional activity during cell-type specification. In recent years, reprogramming, direct programming, and transdifferentiation experiments have taken advantage of this principle to impose cell type-specific gene regulatory programs. This study examined the contribution of a series of TFs to specific neuronal regulatory programs using...

    Subject
    Genomics
    Access Rights
    Free to All