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  • Quantitative Structured Office Measurements of Movements in the Extremities

    Authors
    Timothy P. Harrigan
    Brian J. Hwang
    Anil K. Mathur
    Kelly A. Mills
    10 more author(s)...
    Description

    To test a low-cost system for obtaining continuous quantitative measurements of movements of people with Parkinson’s disease (PD), investigators attached accelerometers to the upper and lower extremities of twenty patients with Parkinson’s disease, one patient with multiple system atrophy (MSA) (participant 4), and eight age- and sex-matched healthy controls (HC) who performed twelve tasks modified...

    Subject
    Chronic Disease
    Neuroscience
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  • Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome

    Authors
    James Robert Brasic
    Ayon Nandi
    David S. Russell
    Danna Jennings
    7 more author(s)...
    Description

    Prior studies have linked dysfunction of metabotropic glutamate receptors (mGluR) to idiopathic autism spectrum disorder (IASD) and fragile X syndrome (FXS). In this study, the investigators evaluated mGluR5 expression in participants with IASD, FXS, and typical development (TD) using positron emission tomography (PET). The Institute for Neurodegenerative Disorders (IND) in New Haven, Connecticut enrolled...

    Subject
    Neuroscience
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  • Signal Processing of Quantitative Continuous Measurement of Movements in the Extremities

    Authors
    Liran Ziegelman
    Manuel E. Hernandez
    Tanvi Kosuri
    Samuel D. Martin
    31 more author(s)...
    Description

    32 raters certified in the administration of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) were presented with two sets of 40 quizzes containing five representations of the ratings of participants with Parkinson's disease (PD) with single sessions for the scoring of (A) output signals and FFTs and (B) CWTs (Pilot Test and Retest). Each panel consisted of six images...

    Subject
    Chronic Disease
    Neuroscience
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  • Feasibility of Sequential Online Motor Assessment of Patients With Parkinson Disease by Multiple Raters in Different Locations

    Authors
    Abdelwahab Elshourbagy
    Samah Mostafa
    Sudqi Allouzi
    Abdelrahman Mohamed
    17 more author(s)...
    Description

    This study recruited 20 remote raters who were certified in the administration of the Movement Disorders Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). The objective was to determine the feasibility of a procedure for conducting sequential online motor assessments for one patient with Parkinson's disease. Each session followed the same protocol led by the principal...

    Subject
    Chronic Disease
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  • NYU Dataset

    Mapping the Landscape of Histomorphological Cancer Phenotypes Using Self-Supervised Learning on Unannotated Pathology Slides

    Authors
    Adalberto Claudio Quiros
    Nicolas Coudray
    Anna H. Yeaton
    Xinyu Yang
    12 more author(s)...
    Description

    Histomorphological Phenotype Learning (HPL) was developed as a self-supervised methodology to discriminatory features in microscopy images to aid in cancer diagnosis and management. The methodology partitions whole slide images (WSIs) into meaningful Histomorphological Phenotype Clusters (HPCs) that can be used to define and quantify morphological phenotypes which recur within and between cases. HPL...

    Subject
    Cancer
    Chronic Disease
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    Free to All
    Author Approval Required
  • NYU Dataset

    Feasibility of reliable, remote assessment of a 13-year-old boy who stopped talking

    Authors
    Neeraj Kadubandi
    Abdelwahab Elshourbagy
    Faraz Azhar
    James Robert Brasic
    Description

    To develop and evaluate a potential comprehensive instrument for the assessment of catatonia in the pediatric population, the investigators reviewed a recording of clinical assessments undertaken with a 13 year old patient. The video was shown once before the raters independently completed each of the following assessments to determine inter-rater agreement: Bush-Francis Catatonia Rating Scale; Pediatric...

    Subject
    Mental Health
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    Free to All