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NYU Dataset
Evolutionarily Central Synaptic Role of Ku, X4L4, and XLF in NHEJ Synapsis
- Authors
- Bailin ZhaoGo WatanabeMichael J. MortenDylan A. Reid2 more author(s)...
- Description
NHEJ is the dominant double-strand break (DSB) repair pathway. During synapsis, the two DNA ends at a DSB are brought together into physical proximity for DNA repair. Using single-molecule FRET (smFRET), the study showed that both Ku and XRCC4:DNA ligase IV (X4L4) are necessary to achieve a flexible synapsis of blunt DNA ends. The addition of XLF causes a transition to a close synaptic state and the...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability
- Authors
- Vladislav O. SviderskiyLili BlumenbergElizabeth GorodetskyTriantafyllia Karakousi13 more author(s)...
- Description
This study showed that basal-like breast cancer (BLBC) is sensitive to suppression of iron-sulfur cluster (ISC) biosynthesis and identified DNA polymerase epsilon (POLE) as an ISC-containing protein that underlies this phenotype. This dataset includes primary RNA sequencing data and other primary data, as well as supplementary data tied to the publication. The supplementary data contains tables, which...
- Subject
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Genomics
- Access Rights
- Free to All