NYU Data Catalog

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  • NYU Dataset

    Evolutionarily Central Synaptic Role of Ku, X4L4, and XLF in NHEJ Synapsis

    Authors
    Bailin Zhao
    Go Watanabe
    Michael J. Morten
    Dylan A. Reid
    2 more author(s)...
    Description

    NHEJ is the dominant double-strand break (DSB) repair pathway. During synapsis, the two DNA ends at a DSB are brought together into physical proximity for DNA repair. Using single-molecule FRET (smFRET), the study showed that both Ku and XRCC4:DNA ligase IV (X4L4) are necessary to achieve a flexible synapsis of blunt DNA ends. The addition of XLF causes a transition to a close synaptic state and the...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability

    Authors
    Vladislav O. Sviderskiy
    Lili Blumenberg
    Elizabeth Gorodetsky
    Triantafyllia Karakousi
    13 more author(s)...
    Description

    This study showed that basal-like breast cancer (BLBC) is sensitive to suppression of iron-sulfur cluster (ISC) biosynthesis and identified DNA polymerase epsilon (POLE) as an ISC-containing protein that underlies this phenotype. This dataset includes RNA sequencing data and data underlying figures. The publication also contains supplementary data, which includes data for short hairpin RNA (shRNA)...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All