NYU Data Catalog

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  • NYU Dataset

    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability

    Authors
    Vladislav O. Sviderskiy
    Lili Blumenberg
    Elizabeth Gorodetsky
    Triantafyllia Karakousi
    13 more author(s)...
    Description

    This study showed that basal-like breast cancer (BLBC) is sensitive to suppression of iron-sulfur cluster (ISC) biosynthesis and identified DNA polymerase epsilon (POLE) as an ISC-containing protein that underlies this phenotype. This dataset includes RNA sequencing data and data underlying figures. The publication also contains supplementary data, which includes data for short hairpin RNA (shRNA)...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    An eIF3d-Dependent Switch Regulates Human Cytomegalovirus Replication

    Authors
    Letitia Thompson
    Daniel P. Depledge
    Hannah M. Burgess
    Ian Mohr
    Description

    Gene expression rapidly responds to physiological stress like virus infection in part via the control of mRNA translation. However, how translation of virus and host mRNAs are regulated during infection stress remains unknown. This study showed that protein synthesis in human cytomegalovirus (HCMV)-infected cells unexpectedly becomes progressively reliant upon eIF3d, which is a mRNA cap-binding protein...

    Subject
    Genomics
    Access Rights
    Free to All