NYU Data Catalog

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  • NYU Dataset

    Therapeutic Insights into Overcoming Therapy Resistance in BRAFV600E Melanoma

    Authors
    Ze-Yan Zhang
    Yingwen Ding
    Ravesanker Ezhilarasan
    Tenzin Lhakhang
    9 more author(s)...
    Description

    Although targeted cancer therapies have been successful, their efficacies are limited by the development of resistance driven by clonal evolution within tumors. This study developed a single-cell barcoding approach to comprehensively trace clonal dynamics and capture live lineage-coupled resistant cells for in-depth multi-omics analysis and functional exploration. They showed that heterogeneous clones,...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    NR2F2 Isoform Unleashes a Metastatic Program in Melanoma

    Authors
    Veronica Davalos
    Claudia D. Lovell
    Richard Von Itter
    Igor Dolgalev
    17 more author(s)...
    Description

    This study described DNA methylation changes that accompany metastatic progression in melanoma patients and found localized methylation changes in the regulatory region of NR2F2. NR2F2 is an orphan-nuclear receptor that is essential for embryonic and neural crest cell (NCC) development. For this study, they examined DNA methylation profiles of NCCs and melanocytes as well as melanoma patient tissues...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All