NYU Data Catalog

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  • NYU Dataset

    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability

    Authors
    Vladislav O. Sviderskiy
    Lili Blumenberg
    Elizabeth Gorodetsky
    Triantafyllia Karakousi
    13 more author(s)...
    Description

    This study showed that basal-like breast cancer (BLBC) is sensitive to suppression of iron-sulfur cluster (ISC) biosynthesis and identified DNA polymerase epsilon (POLE) as an ISC-containing protein that underlies this phenotype. This dataset includes RNA sequencing data and data underlying figures. The publication also contains supplementary data, which includes data for short hairpin RNA (shRNA)...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    KaryoCreate: A CRISPR-Based Technology to Study Chromosome-Specific Aneuploidy

    Authors
    Nazario Bosco
    Aleah Goldberg
    Xin Zhao
    Joseph C. Mays
    24 more author(s)...
    Description

    This study described karyotype CRISPR engineered aneuploidy technology (KaryoCreate), a system that enables generation of chromosome-specific aneuploidies by co-expression of an sgRNA targeting chromosome-specific CENPA-binding ɑ-satellite repeats together with dCas9 fused to mutant KNL1. They designed unique and highly specific sgRNAs for 19 of the 24 chromosomes. To examine the activity of the predicted...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All