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NYU Dataset
Structural Basis of Ion-Substrate Coupling in the Sodium-Dependent Dicarboxylate Transporter VcINDY
- Authors
- David B. SauerJennifer J. MardenJoseph C. SudarJinmei Song2 more author(s)...
- Description
VcINDY is a sodium-dependent dicarboxylate transporter that imports tricarboxylic acid cycle intermediates across the inner membrane of Vibrio cholerae. This study used a combination of structure determination by single-particle cryo-electron microscopy, substrate-binding affinity measurements by intrinsic tryptophan fluorescence quenching, and position accessibility quantification by site-directed...
- Subject
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Proteomics
- Access Rights
- Free to All
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NYU Dataset
Unravelling Cysteine-Deficiency-Associated Rapid Weight Loss
- Authors
- Alan VargheseIvan GusarovBegona Gamallo-LanaDaria Dolgonos13 more author(s)...
- Description
The growing interest in diets that induce weight loss prompted this study to compare restriction of each individual essential amino acid (EAA) and cysteine. For the study, each of the essential amino acids (EAAs) and cysteine were individually removed from diet in Cse−/− and Cse+/− mice to induce weight loss. To evaluate the molecular responses triggered by cysteine deprivation, bulk RNA-sequencing...
- Subject
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Genomics
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NYU Dataset
Mechanism of Beta-Arrestin 1 Mediated Src Activation via Src SH3 Domain
- Authors
- Natalia PakharukovaBrittany N. ThomasHarsh BansiaLinus Li12 more author(s)...
- Description
Beta-arrestins (βarrs) are key transducers of G-protein coupled receptors, but the mechanisms of βarr signaling are poorly understood. Therefore, this study examined the structural mechanisms underlying βarr-mediated signal transduction. Using cryo-electron microscopy (cryo-EM), the study examined how βarr1 recruits and activates the non-receptor tyrosine kinase Src, a well-established signaling partner...
- Subject
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Proteomics
- Access Rights
- Free to All