NYU Data Catalog

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Results Found: 4
  • NYU Dataset

    Oxidative Phosphorylation Is Dysregulated Within the Basocortical Circuit in Mouse Model of Down Syndrome and Alzheimer’s Disease

    Authors
    Melissa J. Alldred
    Sang Han Lee
    Grace E. Stutzmann
    Stephen D. Ginsberg
    Description

    Neurological dysfunction associated with Down syndrome (DS) is the concomitant basal forebrain cholinergic neuron (BFCN) degeneration and onset of Alzheimer’s disease (AD) pathology. Previously, single population RNA sequencing analysis in the Ts65Dn (Ts) mouse model of DS revealed that the mitochondrial oxidative phosphorylation pathway was significantly impacted, where a large subset of genes within...

    Subject
    Neuroscience
    Proteomics
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  • NYU Dataset

    Selective Decline of Neurotrophin and Neurotrophin Receptor Genes Discovered From Rush Religious Orders Study

    Authors
    Stephen D. Ginsberg
    Michael H. Malek-Ahmadi
    Melissa J. Alldred
    Shaoli Che
    7 more author(s)...
    Description

    This study profiled neurotrophin and neurotrophin receptor gene expression within microdissected CA1 neurons along with regional hippocampal dissections from participants in the Rush Religious Orders Study (RROS). The RROS participants included older religious clergy who have agreed to medical and psychological evaluation each year and brain donation after death. This study began in 1993 and has enrolled...

    Subject
    Genomics
    Neuroscience
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  • NYU Dataset

    Predictors of Neuritic Plaque and Neurofibrillary Tangle Pathology Determined From Rush Religious Orders Study

    Authors
    Stephen D. Ginsberg
    Michael H. Malek-Ahmadi
    Melissa J. Alldred
    Yinghua Chen
    4 more author(s)...
    Description

    This study investigated whether the Alzheimer’s disease (AD) pathological lesions diffuse plaques (DPs), neuritic plaques (NPs), and neurofibrillary tangles (NFTs). For this study, downregulation of brain-derived neurotrophic factor (BDNF) and its cognate neurotrophin receptor, TrkB, were observed during the progression of dementia. They performed negative binomial (NB) regressions using gene expression...

    Subject
    Neuroscience
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  • NYU Dataset

    Long-term priors influence visual perception through recruitment of long-range feedback

    Authors
    Richard Hardstone
    Michael Zhu
    Adeen Flinker
    Lucia Melloni
    6 more author(s)...
    Description

    The investigators recruited 14 adult patients undergoing evaluation at NYU Comprehensive Epilepsy Center prior to surgery, 24 healthy volunteers participating in-person, and 60 healthy volunteers participating online for experiments to examine the influence of long-term prior knowledge ('priors') on perception. Bistable perception task: 14 epilepsy patients who were undergoing surgical evaluation...

    Subject
    Chronic Disease
    Neuroscience
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    Free to All