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  • NYU Dataset

    Genome-Wide Screening Identifies Trim33 as an Essential Regulator of Dendritic Cell Differentiation

    Authors
    Ioanna Tiniakou
    Pei-Feng Hsu
    Lorena S. Lopez-Zepeda
    Gorkem Garipler
    16 more author(s)...
    Description

    The development of dendritic cells (DCs) are controlled by the growth factor Flt3 ligand (Flt3L) and its receptor Flt3. This study contained in vitro CRISPR/Cas9-based dropout genetic screening of DC differentiation from HoxB8-FL cells, in vitro validation of the inhibition of mammalian target of rapamycin (mTOR) signaling as a requirement for HoxB8-FL differentiation, and in vivo validation of select...

    Subject
    Genomics
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