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NYU Dataset
Genome-Wide Screening Identifies Trim33 as an Essential Regulator of Dendritic Cell Differentiation
- Authors
- Ioanna TiniakouPei-Feng HsuLorena S. Lopez-ZepedaGorkem Garipler16 more author(s)...
- Description
The development of dendritic cells (DCs) are controlled by the growth factor Flt3 ligand (Flt3L) and its receptor Flt3. This study contained in vitro CRISPR/Cas9-based dropout genetic screening of DC differentiation from HoxB8-FL cells, in vitro validation of the inhibition of mammalian target of rapamycin (mTOR) signaling as a requirement for HoxB8-FL differentiation, and in vivo validation of select...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Synergistic Activation by Glass and Pointed Promotes Neuronal Identity in the Drosophila Eye Disc
- Authors
- Hongsu WangKomal Kumar Bollepogu RajaKelvin YeungCarolyn A. Morrison8 more author(s)...
- Description
This study demonstrated that synergistic activation by two transcription factors, Pointed (Pnt) and Glass (Gl), drives a program of neuronal gene expression in developing Drosophila photoreceptors. Differentiation of photoreceptors R1–R7 requires epidermal growth factor (EGFR) signaling. The intrinsic zinc finger transcription factor Gl is expressed in all eye disc cells beginning just prior to their...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Foxa2 and Pet1 Direct and Indirect Synergy Drive Serotonergic Neuronal Differentiation
- Authors
- Begum AydinMichael SierkMireia Moreno-EstellesLink Tejavibulya4 more author(s)...
- Description
Transcription factors (TFs) are the key players controlling transcriptional activity during cell-type specification. In recent years, reprogramming, direct programming, and transdifferentiation experiments have taken advantage of this principle to impose cell type-specific gene regulatory programs. This study examined the contribution of a series of TFs to specific neuronal regulatory programs using...
- Subject
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Genomics
- Access Rights
- Free to All
